An unbiased screen identifies a CD137xPD-L1 bispecific IgG1 antibody with unique T cell activation and binding properties

Cecile A. Geuijen1, Paul Tacken1, Rinse Klooster1, Horacio Nastri2, Shaun Stewart2, Jing Zhou2, Steve Wang2, Cheng-Yen Huang2, Arjen Kramer1, Linda Kaldenberg-Hendriks1, John de Kruif1, Renate den Blanken-Smit1, Vanessa Zondag-van de Zande1, Abdul Basmeleh1, Willem Bartelink1, Patrick Mayes2, Gregory Hollis2, Reid Huber2, Mark Throsby11Merus NV, Utrecht, Netherlands; 2Incyte Corporation, Wilmington, DE.

Poster presented at the American Association for Cancer Research (AACR) 2019 Annual Meeting, Atlanta, GA, USA.