A bispecific Fc-silenced IgG1 antibody (MCLA-145) requires PD-L1 binding to activate CD137

Patrick Mayes1, Paul Tacken2, Steve Wang1, Pieter-Fokko van Loo2, Thomas Condamine1, Hans van der Maaden2, Eric Rovers2, Steef Engels2, Floris Fransen2, Ashwini Kulkarni1, Yao-bin Liu1, Arpita Mondal1, Leslie Hall1, Soyeon Kim3, Marina Martinez3, Shaun O’Brien3, Edmund Moon3, Steven Albelda3, Peggy Scherle1, Gregory Hollis1, Reid Huber1, Mark Throsby2, Cecile A. Geuijen21Incyte Corporation, Wilmington, DE; 2Merus NV, Utrecht, Netherlands; 3University of Pennsylvania, Philadelphia.

Poster presented at the American Association for Cancer Research (AACR) 2019 Annual Meeting, Atlanta, GA, USA.